On February 23, 2018, the National Toxicology Program (NTP) released for public comment a draft report on the findings of a comprehensive two-year rodent study examining the potential effects of Bisphenol A (BPA) on health.
The study was conducted by senior scientists at the FDA’s National Center for Toxicological Research (NCTR). The study is part of a collaborative effort called the Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA), which was established by the FDA and the National Institute of Environmental Health Sciences (NIEHS) of the National Institutes of Health after a 2008 NTP report raised some concerns about developmental effects in rodents exposed to relatively low doses of BPA. Experts from federal agencies and academic grantees worked together to design and conduct studies through the CLARITY-BPA research program to address concerns raised in the 2008 NTP report.
Stephen Ostroff M.D., the FDA’s Deputy Commissioner for Foods and Veterinary Medicine, issued a statement regarding the NTP’s draft report on BPA. The FDA has authorized the use of BPA in polycarbonate plastics and epoxy resins in certain food and beverage can linings. Dr. Ostroff announced that, after its initial review of the NTP report, the FDA continues to conclude that BPA is safe for its currently authorized uses.
The study looked at the effects of several different doses of BPA and evaluated chronic and early life exposure in two different groups of rodents. The doses ranged from low doses that would be comparable to typical human exposures, to doses that vastly exceed human exposures. A variety of endpoints were evaluated including growth, weight, and tumor development. Overall, the study found minimal effects for the BPA-dosed groups of rodents. The report did identify some areas that may merit further research, such as the increase in occurrence of mammary gland tumors.
See the FDA Announcement
See the NTP Draft Report
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